We use engineering approaches to develop 1) new therapies that promote regeneration of brain and spinal cord tissues and 2) improved preclinical models of brain tumors.

A common theme across many pathologies of central nervous system, including cancer and spinal cord injury, is significant alterations to the extracellular matrix, such as changes in biochemical composition and structural mechanics of the tissue. A lack of understanding of how the extracellular matrix is fundamentally altered by injury or disease, and thus how these changes may be reversed to restore normal function, has been a major limitation to the development of new treatments. My lab develops tools for investigating the unique extracellular environment in the central nervous system and its relationship to cell function. We use biomimetic, hydrogel-based microenvironments with modular features that can be tuned to quantify independent effects of various extracellular parameters over cell phenotype and behavior and, in turn, provide a means for precise external control over cell and tissue function. Furthermore, we are developing methods for high-throughput assays of live cells cultured within these same biomaterial platforms. Acquisition of dynamic, high-throughput data from cells cultured in physiologically relevant conditions will provide new insights into pathologies of the central nervous system and, ultimately, more effective therapies for these conditions.

News

Jun 08, 2021

Lab Manager position is available in the lab of Stephanie Seidlits in the Department of Biomedical Engineering at the University of Texas at Austin (earliest start date January 2022).

Lab Manager position is available in the lab of Stephanie Seidlits in the Department of Biomedical Engineering at the University of Texas at Austin (earliest start date October 2021). Our research seeks to develop clinical therapies for central nervous system injuries and disorders, including spinal cord injury, traumatic brain injury, and brain cancers. The Lab Manager is expected to run…
Jun 07, 2021

Multiple post-doctoral positions are available in the lab of Stephanie Seidlits in the Department of Biomedical Engineering at the University of Texas at Austin (earliest start date January 2022)!

Multiple post-doctoral positions are available in the lab of Stephanie Seidlits in the Department of Bioengineering at the University of Texas at Austin (earliest start date January 2022). The Seidlits lab is a highly collaborative environment. Positions will involve working with other researchers in the lab (e.g., undergraduate and graduate students) and collaborators in other labs. Specific responsibilities will include…
Jun 07, 2021

The Seidlits lab is moving to the Biomedical Engineering Department at the University of Texas at Austin in 2022!

I am excited to announce that Seidlits lab is moving to the Biomedical Engineering Department at the University of Texas at Austin in 2022! We are excited to embark on this new adventure with support from the Cockrell School of Engineering and a $4 million Recruitment of Rising Star Award from CPRIT. https://www.bme.utexas.edu/news/texas-bme-alum-and-cprit-rising-star-seidlits-to-join-bme-department https://www.cprit.texas.gov/news-events/articles/cancer-prevention-research-institute-of-texas-awards-695-million-in-new-grants/
Jun 02, 2021

Congratulations to Dr. Alireza Sohrabi!

Alireza had his PhD defense today and passed with flying colors! The committee members were all very impressed at the extent of the work he has accomplished during the past several years. Very excited to see the great work that Dr. Sohrabi will continue to produce in the future!
May 03, 2021

Congratulations to Dr. Jessica Chen!

Jessica has been awarded Jack & Fay Netchin Medical Student Summer Fellowship from the American Brain Tumor Association to work full-time over the summer developing better glioblastoma models.

Copyright 2017 Seidlits Research Group © All Rights Reserved | UCLA